Intestinal Disease That Killed Francis Drake

Puzzle 6 of Baking a Cake Hard Pack

Question is: Intestinal Disease That Killed Francis Drake

and the answer is: DYSENTERY

Word Meaning:

DYSENTERY — (pathology) A disease characterised by inflammation of the intestines, especially the colon (large intestine), accompanied by pus (white blood cells) in the feces, fever, pain in the abdomen, high-volume diarrhea, and possible blood in the feces.

Definitions from Wiktionary.