Pointlessness, Hopelessness
This page is the CodyCross answer for the clue below from La Bella Roma, Group 410, Puzzle 5 (The Holy See).
Question is: Pointlessness, Hopelessness
and the answer is: FUTILITY
Word Meaning:
FUTILITY — (uncountable) The quality of being futile or useless.
Definitions from Wiktionary.